化学化工学院教授、博士、博导

邮箱：xwju@swu.edu.cn

教育经历

1990.07获重庆大学材料学院学士学位

2003.06-2009.06获西南师范大学/西南大学分析化学专业硕士/博士学位

研究及工作经历

2013.10-2014.10获国家留学基金委资助，在美国堪萨斯大学化学系（生物分析化学Ralph N. Adams研究所）杰出教授George S. Wilson实验室做访问研究

研究方向

生物传感器（Biosensors）、生物电分析化学（Bio-electroanalysis）及纳米生物技术（Nanobiotechnology）

科研项目

主持国家自然科学基金“环境内分泌干扰物暴露下乳腺癌多元标志物电化学检测新方法研究（22476162）”及重庆市自然科学基金面上项目“石墨炔纳米复合物协同双催化核酸放大构建超灵敏环境甾体雌激素电化学传感新方法研究（CSTB2024NSCQ-MSX0357）”。曾主持国家自然科学基金项目“环介导等温扩增H⁺诱导DNA纳米结构构型转换超灵敏HIV标志物DNA电化学生物传感器研究（21775123）”

近期代表性论著（不超过十项）

1. Jiayang He, Kexin Hu, Min Long, Chunli Yang, Yuqing Zhang, Xinyue Jia, Ruo Yuan, Wenju Xu*. Engineering fluorescence of guanine-activated Ag nanocluster to illuminate label-free, simplified and efficient logic circuits with minimal strand migration, Chem. Eng. J. 2025, 506, 159869.

2. Yuqing Zhang, Chunli Yang, Jiayang He, Zhihan Zhang, Yaqin Chai, Ruo Yuan, Wenju Xu*. Dynamic switching circuit modulated by intramolecular conformation transition of DNA translator for versatile fluorescence biosensors, Biosens. Bioelectron. 2025, Accepted, In press.

3. Honglin Song, Jingjing Ye, Yifu Zhou, Zhixuan Chen, Ruo Yuan, Wenju Xu*. DNA hairpin dimer-mediated dual-catalysis circuit for efficient and amplifiable electrochemical biosensing, Biosens. Bioelectron. 2025, 278, 117332.

4. Zhihan Zhang, Yuqing Zhang, Chunli Yang, Jiayang He, Xinyue Jia, Min Long, Ruo Yuan, Wenju Xu*. Target-responsive conformation switch of bihairpin molecular beacon to illustrate ratiometric fluorescence biosensing of dual-emissive silver nanoclusters, Anal. Chem. 2025, Accepted, In press.

5. Chunli Yang, Yuqing Zhang, Zhaorong Mo, Jiayang He, Zhihan Zhang, Yaqin Chai, Ruo Yuan, Wenju Xu*. A high-efficiency autocatalysis-oriented cascade circuit via reciprocal hug- amplification for assay-to-treat application. Anal. Chem. 2025, 97, 1816-1826

6. Jiayang He, Xin Shang, Min Long, Chunli Yang, Yuqing Zhang, Mengdie Li, Ruo Yuan, Wenju Xu*. Fluorescence biosensing based on bifurcated DNA scaffold-aggregated Ag nanocluster via responsive conformation switch of quasi-molecular beacon, Anal. Chem. 2024, 96, 3480-3488.

7. Chunli Yang, Yanan Shi, Yuqing Zhang, Jiayang He, Zhihan Zhang, Xinyue Jia,  Ruo Yuan, Wenju Xu*. A bivariate fluorescence biosensor based on Janus DNA nanoarchitecture-loaded dual-emissive Ag nanoclusters as bi-responsive signaling reporters, Biosens. Bioelectron. 2024, 263, 116621.

8. Xinyue Jia, Jiayang He, Mengdie Li, Jingjing Ye, Yuqing Zhang, Chunli Yang, Ruo Yuan, Wenju Xu*. Stimulus-responsive four-stranded DNA nanoring assembly to host multiple nanosilver clusters for cooperatively enhanced fluorescence biosensing, Anal. Chem. 2024, 96, 10677-10685.

9. Jiayang He, Shihua Luo, Huilin Deng, Chunli Yang, Yuqing Zhang, Mengdie Li, Ruo Yuan, Wenju Xu*. Fluorescent features and applicable biosensing of a core-shell Ag nanocluster shielded by a DNA tetrahedral nanocage, Anal. Chem. 2023, 95, 14805-14815.

10. Yuqing Zhang, Chunli Yang, Jiayang He, Mengdie Li, Ruo Yuan, Wenju Xu*. Ratiometric fluorescence biosensing of tandem biemissive Ag clusters boosted by confined catalytic DNA assembly, Anal. Chem. 2023, 95, 17928-17936.