个人简介

2003-2009年在西南大学分别获得分析化学硕士和博士学位；2009年至今在西南大学化学化工学院工作。围绕生物体内生化信息的高效获取这一关键科学问题，致力于发光分析的新材料、新方法和新原理的研究；通过设计功能化的核酸纳米结构信号开关，构建了一系列检测疾病标志物，如蛋白、基因及表观遗传物质的高灵敏生物传感技术与方法。目前，以通讯作者身份在J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、Sci. Adv.、 Acc. Mater. Res.、 Sci. China Chem.等国际权威刊物上发表论文120余篇，总引用次数超过13,000次（Web of Science），以第一发明人授权国家发明专利6项。研究成果《多维限域协同增强电化学发光界面的构建与应用基础研究》获重庆市自然科学二等奖（2025年，排名第一）。获得国家自然科学基金优秀青年基金资助（2020年），入选首批重庆英才计划青年拔尖人才（2019年），第四批重庆市学术技术带头人（2024年）。担任发光分析与分子传感教育部重点实验室副主任，西南大学科学技术协会委员会副主席。受邀担任美国化学会Analytical Chemistry编辑顾问委员（Editorial Advisory Board）、学术期刊Chinese Chemical Letters编委；2020-2026全球前2%顶尖科学家榜单之“终生科学影响力榜单”。

研究方向

1．电化学发光与荧光传感分析

2．DNA生物功能材料

3．智能化诊疗平台

代表性论文、专著和专利

[1] Jie Liu, Liuqing Tan, Xiuli Tao, Lu Yan, Ying Zhuo*. Spatially Confined DNA Nanodevices for Sensing and In Situ Imaging of Biomolecules. Acc. Mater. Res., 2026, 7, 976-988.

[2] Xian-Ming Guo, Mei-Ling Zhao, Xia Yang, Xia Zhong, Yan-Mei Lei*, Ying Zhuo*. Logic-Responsive Superspherical Nucleic Acid Enables Tumor-Specific Multiplexed Gene Silencing for Efficient Cancer Therapy. Angew. Chem. Int. Ed., 2026, e7096315.

[3] Xiaoyang Liu, Xianbao Sun, Yu Ma, Qiaochu Jiang, Yun Yin, Hai-Dong Xu, Xiaotong Cheng, Yang Yang, Yinghuan Li, Hongzhe Yan, Xinping Zhang, Xinwang Yu, Wenjun Zhan, Fu-Gen Wu, Xiaofeng Wu, Ying Zhuo*, Gaolin Liang*, Apoptosis-Amplified Intracellular Paclitaxel Nanoparticle Formation Enhances Microtubule Aggregation and PANoptosis. Angew. Chem. Int. Ed. 2026, 65, e17035.

[4] Xue-Mei Zhou, Xiu-Li Tao, Yan-Mei Lei, Xia Yang, and Ying Zhuo*. Dynamic Monitoring Chemoresistant Tumor Cells Enabled by An Adaptive DNA Nanoclassifier. Sci. China Chem. 2026, DOI:10.1007/s11426-026-3541-7.

[5] Zhao-Peng Chen, Wei-Jia Zeng, Yan-Mei Lei, Wen-Bin Liang, Xia Yang, Ruo Yuan, Chaoyong Yang*, Ying Zhuo*. Engineering of a Multi-Modular DNA Nanodevice for Spatioselective Imaging and Evaluation of NK Cell-Mediated Cancer Immunotherapy. Angew. Chem. Int. Ed., 2025, 64, e202414064.

[6] Xiu-Li Tao, Yan-Mei Lei, Xue-Mei Zhou, Zhao-Peng Chen, Yue Ma, Pin-Yi Ma, Da-Qian Song, Ying Zhuo*. Allosteric Activation of Cas12a via PAM Topological Engineering for Direct and Rapid Detection of Nucleases. Angew. Chem. Int. Ed., 2025, e202515521.

[7] Wei Liu, Ni Liao, Yanmei Lei, Wenbin Liang, Xia Yang, Ruo Yuan, Chaoyong Yang*, Ying Zhuo*. Detachable DNA Assembly Module to Dissect Tumor Cells Heterogeneity via RNA Pinpoint Screening. Adv. Sci. 2024, 11, 2401253.

[8] Mei-Ling Zhao, Yan-Mei Lei, Jing-Yi Tang, Wen Li, Xin-Yu Cao, Wen-Bin Liang, Ruo Yuan, Chaoyong Yang, Ying Zhuo*. DNA Lesion-gated Dumbbell Nanodevices Enable On-demand Activation of the cGAS-STING Pathway for Enhancing Cancer Immunotherapy. Chem. Sci. 2024. 16, 1783-1790.

[9] Yanmei Lei, Xiaochen Fei, Yue Ding, Jianhui Zhang, Guihua Zhang, Liang Dong, Jia Song, Ying Zhuo*, Wei Xue*, Peng Zhang*, Chaoyong Yang*. Simultaneous Subset Tracing and miRNA Profiling of Tumor-derived Exosomes via Dual-surface-protein Orthogonal Barcoding. Sci. Adv., 2023, 9, eadi1556.

[10] Hao-Ran Chen, Ming-Li Su, Yan-Mei Lei, Zhuo-Xin Ye, Zhao-Peng Chen, Pin-Yi Ma, Ruo Yuan*, Ying Zhuo*, Chao-Yong Yang*, and Wen-Bin Liang*. Insights of Life Molecules’ Dynamic Distribution in Live Cells via Sequence–Structure Bispecific Fluorescent RNA. J. Am. Chem. Soc., 2023, 145, 23, 12812-12822.