化学化工学院教授、博士、博导

邮箱：yqchai@swu.edu.cn

教育经历

2004年毕业于西南大学并获得博士学位

研究及工作经历

1999至2000年在香港城市大学做访问学者

1999年10月于西南大学化学化工学院工作，任西南大学化学化工学院教授、博士生导师

研究方向

1.开展电化学及光致电化学生物分析策略研究

2.结合分子识别（免疫、适体及DNA、MicroRNA及细胞）及多种信号放大策略，构建生物传感器用于疾病标志物及肿瘤细胞检测评估研究。

3.电化学及光致电化学分析生物成像分析研究

科研项目

1.国家自然科学基金面上项目：高效无酶核酸放大超灵敏电致化学发光传感器用于环境污染物暴露与肝癌microRNA标志物表达水平微小变化的相关性研究，2022.01-2025.12

2.国家自然科学基金面上项目：钌配合物功能化聚乙烯亚胺电致化学发光材料的制备及其在免疫传感器中的应用，2015.01-2018.12

3.重庆市自然科学基金重点项目：基于功能化纳米材料的重金属离子电化学传感器构建及其在环境分析中的应用，2011.04-20.14.3

近期代表性论著（不超过十项）

1. Zhang, Pu; Jiang, Jie; Yuan, Ruo*; Zhuo, Ying*; Chai, Yaqin*. Highly ordered and field-free 3D DNA nanostructure: the next generation of DNA nanomachine for rapid single-step sensing. J. Am. Chem. Soc., 2018, 140, 9361

2. Kou, Beibei; Chai, Yaqin*; Yuan, Yali*; Yuan, Ruo*. A DNA nanopillar as a scaffold to regulate the ratio and distance of mimic enzymes for an efficient cascade catalytic platform. Chem. Sci., 2021, 12, 407

3. Zhang, Xiaolong; Yang, Zhehan; Chang, Yuanyuan; Liu, Di; Li, Yunrui; Chai, Yaqin*; Zhuo, Ying*; Yuan, Ruo*. Programmable mismatch-fueled high-efficiency DNA signal converter. Chem. Sci., 2020, 11, 148

4. Liu, Jiali; Zhang, Jiaqi; Tang, Zhiling; Zhuo, Ying; Chai, Yaqin*; Yuan, Ruo*. Near-infrared aggregation-induced enhanced electrochemiluminescence from tetraphenylethylene nanocrystals: a new generation of ECL emitters. Chem. Sci., 2019, 10, 4497

5. Long Linlin, Hu Wenxi, Wang Xin, Yuan Ruo*, Chai Yaqin*. Antibody-protein-aptamer electrochemical biosensor based on highly efficient proximity-induced DNA hybridization on tetrahedral DNA nanostructure for sensitive detection of insulin-like growth factor-1. Anal. Chem., 2024,96(9),3837

6.Zhao Xinyan, Liu Linlei, Xu Yuanqi, Xiang Lian, Yuan Ruo*, Chai Yaqin*. Dual-ligand europium-organic gels as a highly efficient anodic annihilation electrochemiluminescence emitter for ultrasensitive detection of microRNA. Anal. Chem., 2024,96(24),9961

7. Zhou Pan, Zhu Xiaochun, Wang Xiaofeng, Yuan Ruo*, Chai Yaqin*. Protein-Induced Electrochemiluminescence Enhancement of Tetraphenylvinyl Derivatives for Ultrasensitive Bioanalysis. Anal. Chem. 2024,96(42),19473

8. Han Yichen, Jiang Mengshi, Zhou Jie, Lei Hongmin, Yuan Ruo*, Chai Yaqin*. The acid-stimulated self-assembled DNA nanonetwork for sensitive detection and living cancer cell imaging of microRNA-221.Anal. Chem. 2024,96(42),16715