其他成员(姓氏笔画为序)
陈敏 教授
发布时间: 2025-05-29 16:43 作者:本站编辑 来源: 本站原创 浏览次数:

药学院教授、博士、博导

邮箱:mminchen@swu.edu.cn

教育经历

1994.09-1998.06 西南师范大学生命科学学院,本科

1998.09-2001.06 西南师范大学生命科学学院,硕士

2001.09-2004.06 复旦大学药学院,博士

研究及工作经历

2009.01-2009.04 英国格林多大学(Glyndwr University),访问学习

2011.03-2012.09 加拿大不列颠哥伦比亚大学(UBC)化学系,访问学者

2004.07-2013.06 西南大学,副教授

2013.07-至今 西南大学药学院,教授

研究方向

1.中药质量分析与质量控制

2.中药药效物质基础

3.天然产物提取分离与结构鉴定

科研项目

1. 国家自然基金面上项目,基于FXR靶点探讨藏药波棱瓜子木脂素抗NASH活性成分及作用机制研究,822742022023-2026

2. 国家自然基金面上项目,基于RIP1/RIP3介导的程序性坏死致肝损伤假说研究翼首草小毒物质基础及其机制,820741192021-2024

3. 国家自然基金面上项目,基于代谢组学与血清药物化学整体辨识波棱瓜子抗胆汁淤积药效物质基础及其作用机制研究,817740052018-2021

4. 国家自然基金青年基金,藏药巴朱抗肿瘤活性成分快速发现及作用机制研究,811028942012-2014

5. 国家863项目,甘薯花色素苷和β-胡萝卜素植物生物反应器研制,2011AA1006072011-2016

近期代表性论著(不超过十项)

1. Fancheng Meng#, YingXiong Ma#, HongHong Zhan, Wei Zong, Lang Linghu, Zhe Wang, XiaoZhong Lan, ZhiHua Liao, and Min Chen*. Lignans from the seeds of Herpetospermum pedunculosum and their farnesoid X receptor-activating effect. Phytochemistry. 2022, 193, 113010.

2. Jingxin Mao#, Honghong Zhan#, Fancheng Meng, Guowei Wang, Dan Huang, Zhihua Liao, and Min Chen*. Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro. Phytotherapy Research. 2022, 36:1268–1283.

3. Xiaodong Wei, Yingxiong Ma, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Zhihua Liao, and Min Chen*. Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor. Phytomedicine. 2021. 80: 153378.

4. Rui Wang, Zhaoyue Dong, Fancheng Meng, Lin Wei, Guowei Wang, Siyu Zhou, Xiaozhong Lan, Zhihua Liao, and Min Chen *. Pterocephin A, a novel triterpenoid saponin from Pterocephalus hookeri induced liver injury by Activation of Necroptosis. Phytomedicine. 2021. 85, 153548.

5. Fancheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, Guowei Wang, ZhiHua Liao, and Min Chen *. Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism. Phytomedicine. 2021. 87153588.

6. Zhaoyue Dong, Lin Wei, Huiqiang Lu, Qinghong Zeng a, Fancheng Meng, Guowei Wang, Xiaozhong Lan, Zhihua Liao, Min Chen *. Ptehoosines A and B: Two New Sesamin-type Sesquilignans with Antiangiogenic Activity from Pterocephalus hookeri (C.B. Clarke) Höeck. Fitoterapia. 2021. 151, 104886.

7. Xiaodong Wei, Xudong Fan, Zhiying Feng, Yingxiong Ma, Xiaozhong Lan, and Min Chen*. Ethyl acetate extract of Herpetospermum pedunculosum alleviates α-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and suppressing oxidative stress and inflammation in rats. Phytomedicine. 2020, 153257.

8. Zhaoyue Dong, Liqing Deng, Jingqiu Ge, Yingxiong Ma, Hong Quan, Xiaozhong Lan, Zhihua Liao, and Min Chen*. Pharmacokinetics and tissue distribution study of herpetotriol in rats by ultra-high performance liquid chromatography with tandem mass spectrometry. Canadian Journal of Physiology and Pharmacology, 2020, 98(6): 366-372.

国家专利

1. 陈敏; 宗伟; 廖志华; 曾庆鸿; 韦琳; 孟凡成. 青花椒挥发油在制备抗炎或镇痛药物中的应用。中国发明专利.ZL 202011077130.7.

2. 陈敏; 廖志华; 魏小东; 马英雄. 去氢双松柏醇或主要有效成分为去氢双松柏醇的提取物在制备抗肝损伤的药物中的应用. 中国发明专利. 201910639526.7.

3. 陈敏; 王睿; 董召月; 廖志华. 翼首草毒素A及其应用和低肝损伤毒性翼首草提取物的制备方法. 中国发明专利. 专利号: 2019111356883.3.

4. 陈敏; 廖志华; 付玉凡; 谌金吾; 魏文丽. 发明专利;一种紫肉甘薯红色素有效组分的分离及检测方法. 中国发明专利. 专利号: ZL201010226637.4.

5. 陈敏; 廖志华; 兰小中; 徐冰. 发明专利: 一种从波棱瓜中提取具有抗菌活性组分的方法. 中国发明专利. 专利号:  ZL 201010559086.3.