化学化工学院教授、博士、博导

邮箱：xwju@swu.edu.cn

教育经历

1990.07获重庆大学材料学院学士学位

2003.06-2009.06获西南师范大学/西南大学分析化学专业硕士/博士学位

研究及工作经历

2013.10-2014.10获国家留学基金委资助，在美国堪萨斯大学化学系（生物分析化学Ralph N. Adams研究所）杰出教授George S. Wilson实验室做访问研究

研究方向

1.灵敏响应性生物传感检测平台研究

2.DNA纳米组装设计合成及生物学性能研究

科研项目

1. 国家自然科学基金面上项目，2018.01-2021.12

2. 重庆市自然科学基金基础研究与前沿探索项目，2018.07-2021.06

近期代表性论著（不超过十项）

1. Chong Li, Zehui Chen, Yuxuan Zhang, Jiayang He, Ruo Yuan, Wenju Xu*. Guanine-lighting- up fluorescence biosensing of silver nanoclusters populated in functional DNA constructs by a pH-triggered switch, Analytical Chemistry, 2020, 92, 13369

2. Jiayang He, Yuxuan Zhang, Zehui Chen, Chong Li, Ruo Yuan, Wenju Xu*. Targeted DNA- driven catalytic assembly light-up ratiometric fluorescence of biemissive silver nanoclusters for amplified biosensing, Chemical Communications, 2020, 56, 10325

3. Yumeng Liao, Shijing Guo, Xiaoyu Hua, Ruo Yuan, Wenju Xu*. Autocatalytic replicated Mg2+-ligation DNAzyme as robust biocatalyst for sensitive, label-free and enzyme-free electrochemical biosensing of protein, Sensors & Actuators: B. Chemical, 2020, 310, 127862

4. Wenting Yang, Yu Shen, Danyang Zhang, Chong Li, Ruo Yuan, Wenju Xu*. Programmed dual-functional DNA tweezer for simultaneous and recognizable fluorescence detection of microRNA and protein, Analytical Chemistry, 2019, 91, 7782

5. Xiaoyu Hua, Enfen Yang, Wenting Yang, Ruo Yuan, Wenju Xu*. LAMP-generated H+ ions-induced dimer i-motif as signal transducer for ultrasensitive electrochemical detection of DNA, Chemical Communications, 2019, 55, 12463

6. Chong Li, Wenting Yang, Ruo Yuan, Wenju Xu*. Antibody-responsive signal-off fluorescence of DNA-harbored silver nanoclusters for direct, rapid and sensitive immunoassay, Sensors & Actuators: B. Chemical, 2019, 301, 127148

7. Xiaoyu Hua, Enfen Yang, Danyang Zhang, Yu Shen, Jianmin Zhao, Wenju Xu*. Proximity binding-induced DNA assembly as signal translator and enzymecatalyzed cleavage recycle as signal amplifier for highly sensitive electrochemical assay of target DNA, Sensors & Actuators: B. Chemical, 2019, 281, 864

8. Wetting Yang, Yu Shen, Danyang Zhang, Wenju Xu*. Protein-responsive rolling circle amplification as tandem template to drive amplified transduction of fluorescence signal probes for highly sensitive bioanalysis, Chemical Communications, 2018, 54, 10195

9. Jianmin Zhao, Jiaxi Gao, Ting Zheng, Zhehan Yang, Yaqin Chai, Shihong Chen, Ruo Yuan, Wenju Xu*. Highly sensitive electrochemical assay for Nosema bombycis gene DNA PTP1 via conformational switch of DNA nanostructures regulated by H+ from LAMP, Biosensors and Bioelectronics, 2018, 106, 186

10. Jianmin Zhao, Ting Zheng, Jiaxi Gao, Wenju Xu*. Toehold-mediated strand displacement reaction triggered by nicked DNAzymes substrate for amplified electrochemical detection of lead ion, Electrochimica Acta, 2018, 274, 16

国家专利