药学院教授、博士、博导
邮箱：mminchen@swu.edu.cn
教育经历
1994.09-1998.06 西南师范大学生命科学学院，本科
1998.09-2001.06 西南师范大学生命科学学院，硕士
2001.09-2004.06 复旦大学药学院，博士
研究及工作经历
2009.01-2009.04 英国格林多大学(Glyndwr University)，访问学习
2011.03-2012.09 加拿大不列颠哥伦比亚大学(UBC)化学系，访问学者
2004.07-2013.06 西南大学，副教授
2013.07-至今 西南大学药学院，教授
研究方向
1.中药质量分析与质量控制
2.中药药效物质基础
3.天然产物提取分离与结构鉴定
科研项目
1.国家自然基金面，基于RIP1/RIP3介导的程序性坏死致肝损伤假说研究翼首草“小毒”物质基础及其机制，82074119，2021.01-2022.12
2.国家自然基金，基于代谢组学与血清药物化学整体辨识波棱瓜子抗胆汁淤积药效物质基础及其作用机制研究，81774005，2018.01-2021.12
3.国家自然基金，藏药巴朱抗肿瘤活性成分快速发现及作用机制研究，81102894，2012.01-2014.12
4.国家863项目，甘薯花色素苷和β-胡萝卜素植物生物反应器研制，2011AA100607，2011.01-2016.12
5.国家科技支撑计划子课题，红景天代谢工程育种关键技术研究，2011BAI13B06，2011.01-2014.12
近期代表性论著（不超过十项）
1. Xiaodong Wei, Xudong Fan, Zhiying Feng, Yingxiong Ma, Xiaozhong Lan, and Min Chen*. Ethyl acetate extract of Herpetospermum pedunculosum alleviates α-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and suppressing oxidative stress and inflammation in rats. Phytomedicine. 2020, 153257, https://doi.org/10.1016/j.phymed.2020.153257
2. Xiaodong Wei, Yingxiong Ma, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Zhihua Liao, and Min Chen*. Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor. Phytomedicine. 2020, 153378. https://doi.org/10.1016/j.phymed.2020.153378
3. Zhaoyue Dong, Liqing Deng, Jingqiu Ge, Yingxiong Ma, Hong Quan, Xiaozhong Lan, Zhihua Liao, and Min Chen*. Pharmacokinetics and tissue distribution study of herpetotriol in rats by ultra-high performance liquid chromatography with tandem mass spectrometry. Canadian Journal of Physiology and Pharmacology, 2020, 98(6): 366-372, https://doi.org/10.1139/cjpp-2019-0633
4. Guowei Wang*, Xiaolong Zhang, Qinghua Wu, Yongbiao Jin, ChunTao Ning, Rui Wang, JingXin Mao, Min Chen*. The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition. Phytoedicine. 2019, 53: 263-273. https://doi.org/10.1016/j.phymed.2018.09.023
5. Yingxiong Ma, Hong Wang, Rui Wang, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Hong Quan* Zhihua Liao and Min Chen*. Cytotoxic lignans from the stems of Herpetospermum pedunculosum. Phytochemistry. 2019, 164:102-110. https://doi.org/10.1016/j.phytochem.2019.05.004
6. Liqing Deng, Wei Zong, Xueying Tao, Shuang Liu, Zhiying Feng, Yuping Lin, Zhihua Liao, and Min Chen*. Evaluation of the Therapeutic Effect against Benign Prostatic Hyperplasia and the Active Constituents from Epilobium angustifolium L. Journal of Ethnopharmacology. 2019, 232: 1-10. https://doi.org/10.1016/j.jep.2018.11.045
7. Rui Wang, Zhaoyue Dong, Xiaolong Zhang, Jingxin Mao, Fancheng Meng, Xiaozhong Lan, Zhihua Liao, Min Chen*. Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis. Toxins, 2019, 11, 142. DOI: 10.3390/toxins11030142
8. Jingxin Mao, Man Yia, Rui Wang, Yuanshe Huanga and Min Chen*. Protective Effects of Costunolide against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Frontiers in Pharmacology. 2018, 9: 1469 .DOI: 10.3389/fphar.2018.01469
9. SiYu Zhou; YiJie Hu; FanCheng Meng; ShenYue Qu; Rui Wang; Andersen Raymond J; ZhiHua Liao; Min Chen*. Bacillamidins A⁻G from a Marine-Derived Bacillus pumilus. Marine drugs. 2018, 16, 326; DOI: 10.3390/md16090326.
10. Wenrui Cao, jingqiu Ge, Xin Xie a, Menglin Fan, Xudong Fan, Hong Wang, Zhihua Liao, Xiaozhong Lan, and Min Chen*. Protective Effects of Petroleum Ether Extracts of Herpetospermum caudigerum on α-naphthylisothiocyanate-Induced Acute Cholestasis Rats. Journal of Ethnopharmacology. 2017, 198(1): 139-147. DOI: 10.1016/j.jep.2017.01.003.
国家专利
1. 陈敏;王睿;董召月;廖志华.翼首草毒素A及其应用和低肝损伤毒性翼首草提取物的制备方法.中国发明专利.专利号:2019111356883.3
2. 陈敏;廖志华;付玉凡;谌金吾;魏文丽.发明专利；一种紫肉甘薯红色素有效组分的分离及检测方法.中国发明专利.专利号:ZL201010226637.4
3. 陈敏;廖志华;兰小中;徐冰.发明专利:一种从波棱瓜中提取具有抗菌活性组分的方法.中国发明专利.专利号: ZL201010559086.3
4. 陈敏;廖志华;谌金吾;魏文丽;付玉凡.一种利用大孔树脂富集纯化紫甘薯色素的方法.中国发明专利.专利号:ZL201010226641.0