药学院副教授、博士、硕导

邮箱：qren2014@swu.edu.cn

教育经历

2005.09 — 2009.07 四川大学，化学学院，学士

2009.08 — 2014.05 新加坡国立大学，化学学院，博士

研究及工作经历

2014.08 — 至今 西南大学药学院， 教师

研究方向

1.手性药物的设计、合成及活性研究

2.合成方法学

3.核酸的修饰（核酸的功能化研究）

科研项目

1.新型茚满方酰胺催化的3-羟基-2-氧化吲哚类肿瘤抑制剂的不对称合成（21602179）； 国家自然科学基金青年基金； 2017.01-2019.12

近期代表性论著（不超过十项）

1.Ren, Q. *, Li, M.; Yuan, L.; Wang, J. * "Recent advances in N-heterocyclic carbene catalyzed achiral synthesis", Org. Biomol. Chem., 2017, 15, 4731

2.Ren, Q. *; Li, M.; Yuan, L. * “Expeditious assembly of fused dihydropyranones via N-heterocyclic carbene-catalyzed tandem Michael addition/lactonization”, Org. Biomol. Chem., 2017, 15, 1329

3.Ren, Q.; Gao, T.; Li, W.; Wan, L.; Hu, Y.; Peng, Y.; Sun, S.; Hu, L.; Wu, M.; Guo, H.; Wang, J. * “A Highly Enantioselective Michael Reaction between α,β-Unsaturated Ketones and Malonic Acid Half-thioesters”, New J. Chem. 2015, 39, 5100

4.Ren, Q.; Sun, S.; Huang, J.; Li, W.; Wu, M.; Guo, H.; Wang, J. * An Enantioselective Cascade Reaction between α,β-Unsaturated Aldehydes and Malonic Half-thioesters: A Rapid Access to Chiral δ-lactones”, Chem. Commun. 2014, 50, 6137

5. Ren, Q.; Wang, J. * “Recent developments in amine-catalyzed non-asymmetric transformations”, Asian J. Org. Chem. 2013, 2, 542

6.Ren, Q.; Huang, J. Y.; Wang, L.; Li, W. J.; Liu, H.; Jiang, X. F.; Wang, J.* “Highly efficient assembly of 3hydroxy oxindole scaffold via a catalytic decarboxylative [1,2]-addition strategy”, ACS Catal. 2012, 2, 2622

7.Ren, Q.; Siau, W.-Y.; Du, Z. Y.; Zhang, K.; Wang, J.* “Expeditious assembly of a 2-amino-4H-chromene skeleton by using an enantioselective Mannich intramolecular ring cyclization-tautomerization cascade sequence”, Chem. –Eur. J. 2011, 17, 7781

8.Ren, Q.; Gao, Y. J.; Wang, J.* “Chiral indane skeleton based thiourea catalyzed highly stereoselective cascade Michael-enolation-cyclization reaction”, Org. Biomol. Chem. 2011, 9, 5297

9.Ren, Q.; Gao, Y. J.; Wang, J.* “Enantioselective synthesis of densely functionalized pyrano–chromenes via an unpredictable cascade Michael–oxa-Michael–tautomerization sequence”, Chem. –Eur. J. 2010, 16, 13594

10.Zhang, P. *; Feng, S.; Liu, G.; Wang, H.; Zhu, H.; Ren, Q.; Bai, H.; Fu, C.; Dong, C. “Mutant B-Raf (V600E) Promotes Melanoma Paracellular Transmigration by Inducing Thrombin-Mediated Endothelial Junction Breakdown”, J. Biol. Chem. 2016, 291, 2087

国家专利

1.一种具有抗菌活性的R-2-取代-3-硝基-2H-色烯衍生物及其制备方法和应用，任巧、袁吕江、李木瑶、赵筱斐、杨文。ZL 201810463383.4，CN 108409696B2020.07.07